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<p>张博雅 <a href="mailto:&#122;&#108;&#121;&#121;&#122;&#x68;&#x61;&#x6e;&#103;&#x62;&#x6f;&#x79;&#x61;&#64;&#49;&#54;&#x33;&#x2e;&#x63;&#111;&#109;">&#122;&#108;&#121;&#121;&#122;&#x68;&#x61;&#x6e;&#103;&#x62;&#x6f;&#x79;&#x61;&#64;&#49;&#54;&#x33;&#x2e;&#x63;&#111;&#109;</a></p>
<p>姚伟涛 <a href="mailto:&#122;&#108;&#121;&#121;&#x79;&#x61;&#x6f;&#119;&#101;&#x69;&#x74;&#97;&#x6f;&#x31;&#52;&#48;&#50;&#x40;&#122;&#x7a;&#x75;&#x2e;&#101;&#100;&#x75;&#46;&#99;&#x6e;">&#122;&#108;&#121;&#121;&#x79;&#x61;&#x6f;&#119;&#101;&#x69;&#x74;&#97;&#x6f;&#x31;&#52;&#48;&#50;&#x40;&#122;&#x7a;&#x75;&#x2e;&#101;&#100;&#x75;&#46;&#99;&#x6e;</a></p>
<p>梁潇潇 <a href="mailto:&#120;&#x69;&#97;&#x6f;&#x6c;&#x69;&#x61;&#110;&#103;&#119;&#x68;&#117;&#x40;&#49;&#54;&#x33;&#x2e;&#x63;&#x6f;&#x6d;">&#120;&#x69;&#97;&#x6f;&#x6c;&#x69;&#x61;&#110;&#103;&#119;&#x68;&#117;&#x40;&#49;&#54;&#x33;&#x2e;&#x63;&#x6f;&#x6d;</a></p>
<p>侯静雨 <a href="mailto:&#x31;&#x35;&#54;&#x33;&#57;&#x31;&#48;&#x36;&#57;&#x36;&#49;&#x40;&#x31;&#54;&#51;&#x2e;&#x63;&#x6f;&#x6d;">&#x31;&#x35;&#54;&#x33;&#57;&#x31;&#48;&#x36;&#57;&#x36;&#49;&#x40;&#x31;&#54;&#51;&#x2e;&#x63;&#x6f;&#x6d;</a></p>
<p>Zhao Ruiying <a href="mailto:&#82;&#x75;&#105;&#121;&#x69;&#x6e;&#x67;&#x2e;&#x7a;&#x68;&#x61;&#x6f;&#x40;&#117;&#116;&#104;&#46;&#116;&#x6d;&#x63;&#46;&#101;&#100;&#117;">&#82;&#x75;&#105;&#121;&#x69;&#x6e;&#x67;&#x2e;&#x7a;&#x68;&#x61;&#x6f;&#x40;&#117;&#116;&#104;&#46;&#116;&#x6d;&#x63;&#46;&#101;&#100;&#117;</a> Tel:1-202-679-6687<br>Website address: <a target="_blank" rel="noopener" href="https://med.uth.edu/ibp/2022/11/01/ruiying-zhao-md-phd/">https://med.uth.edu/ibp/2022/11/01/ruiying-zhao-md-phd/</a> </p>
<p>Lee Dungfang <a href="mailto:&#100;&#x75;&#x6e;&#103;&#x2d;&#x66;&#x61;&#110;&#103;&#46;&#x4c;&#x65;&#x65;&#64;&#117;&#x74;&#104;&#46;&#x74;&#109;&#x63;&#x2e;&#x65;&#x64;&#117;">&#100;&#x75;&#x6e;&#103;&#x2d;&#x66;&#x61;&#110;&#103;&#46;&#x4c;&#x65;&#x65;&#64;&#117;&#x74;&#104;&#46;&#x74;&#109;&#x63;&#x2e;&#x65;&#x64;&#117;</a> Tel:1-202-674-6497<br>Website address: <a target="_blank" rel="noopener" href="https://med.uth.edu/ibp/2022/11/01/dung-fang-lee-phd/">https://med.uth.edu/ibp/2022/11/01/dung-fang-lee-phd/</a></p>
<p>张攀红 </p>
<h2 id="Suggested-reviewers"><a href="#Suggested-reviewers" class="headerlink" title="Suggested reviewers"></a>Suggested reviewers</h2><p>Zhichang Zhang,  <a href="mailto:&#122;&#x7a;&#x63;&#x31;&#x36;&#51;&#x6d;&#97;&#x69;&#x6c;&#x40;&#x31;&#54;&#51;&#x2e;&#99;&#x6f;&#x6d;">&#122;&#x7a;&#x63;&#x31;&#x36;&#51;&#x6d;&#97;&#x69;&#x6c;&#x40;&#x31;&#54;&#51;&#x2e;&#99;&#x6f;&#x6d;</a>,<br>Tu Hu, <a href="mailto:&#122;&#x7a;&#117;&#x68;&#117;&#x74;&#117;&#x40;&#x31;&#54;&#51;&#46;&#99;&#111;&#109;">&#122;&#x7a;&#117;&#x68;&#117;&#x74;&#117;&#x40;&#x31;&#54;&#51;&#46;&#99;&#111;&#109;</a></p>
<p>Xiaojun Ma, <a href="mailto:&#109;&#x61;&#x2d;&#x78;&#105;&#x61;&#111;&#106;&#x75;&#x6e;&#64;&#x66;&#111;&#120;&#x6d;&#97;&#105;&#108;&#46;&#99;&#111;&#109;">&#109;&#x61;&#x2d;&#x78;&#105;&#x61;&#111;&#106;&#x75;&#x6e;&#64;&#x66;&#111;&#120;&#x6d;&#97;&#105;&#108;&#46;&#99;&#111;&#109;</a><br>Jilong Yang, <a href="mailto:&#121;&#97;&#x6e;&#103;&#x6a;&#x69;&#108;&#x6f;&#x6e;&#x67;&#64;&#x74;&#106;&#109;&#117;&#x63;&#104;&#x2e;&#99;&#111;&#109;">&#121;&#97;&#x6e;&#103;&#x6a;&#x69;&#108;&#x6f;&#x6e;&#x67;&#64;&#x74;&#106;&#109;&#117;&#x63;&#104;&#x2e;&#99;&#111;&#109;</a></p>
<h2 id="Emails"><a href="#Emails" class="headerlink" title="Emails"></a>Emails</h2><p>Boya zhang <a href="mailto:&#122;&#x6c;&#121;&#121;&#x7a;&#104;&#97;&#x6e;&#x67;&#x62;&#x6f;&#121;&#97;&#64;&#49;&#x36;&#51;&#46;&#99;&#x6f;&#109;">&#122;&#x6c;&#121;&#121;&#x7a;&#104;&#97;&#x6e;&#x67;&#x62;&#x6f;&#121;&#97;&#64;&#49;&#x36;&#51;&#46;&#99;&#x6f;&#109;</a>； Zhengzhou University;<br>Hua Wei <a href="mailto:&#119;&#101;&#x69;&#x68;&#x75;&#x61;&#122;&#122;&#117;&#64;&#x31;&#54;&#51;&#x2e;&#x63;&#111;&#x6d;">&#119;&#101;&#x69;&#x68;&#x75;&#x61;&#122;&#122;&#117;&#64;&#x31;&#54;&#51;&#x2e;&#x63;&#111;&#x6d;</a><br>Bowen Hu <a href="mailto:&#119;&#x65;&#105;&#x68;&#x75;&#x61;&#x68;&#110;&#x40;&#x31;&#x36;&#51;&#x2e;&#99;&#111;&#109;">&#119;&#x65;&#105;&#x68;&#x75;&#x61;&#x68;&#110;&#x40;&#x31;&#x36;&#51;&#x2e;&#99;&#111;&#109;</a><br>Chunyi shen <a href="mailto:&#x73;&#104;&#101;&#x6e;&#99;&#x68;&#x75;&#x6e;&#121;&#105;&#x7a;&#122;&#117;&#x40;&#x31;&#x36;&#51;&#46;&#x63;&#111;&#109;">&#x73;&#104;&#101;&#x6e;&#99;&#x68;&#x75;&#x6e;&#121;&#105;&#x7a;&#122;&#117;&#x40;&#x31;&#x36;&#51;&#46;&#x63;&#111;&#109;</a><br>Yuanyuan Wang <a href="mailto:&#x34;&#49;&#x34;&#x31;&#x33;&#53;&#x34;&#48;&#x34;&#x40;&#113;&#113;&#x2e;&#x63;&#111;&#x6d;">&#x34;&#49;&#x34;&#x31;&#x33;&#53;&#x34;&#48;&#x34;&#x40;&#113;&#113;&#x2e;&#x63;&#111;&#x6d;</a><br>Yafeng Dong <a href="mailto:&#50;&#x39;&#48;&#x30;&#x35;&#53;&#50;&#x30;&#x30;&#64;&#113;&#x71;&#x2e;&#x63;&#111;&#109;">&#50;&#x39;&#48;&#x30;&#x35;&#53;&#50;&#x30;&#x30;&#64;&#113;&#x71;&#x2e;&#x63;&#111;&#109;</a><br>Wenlong Chang <a href="mailto:&#67;&#54;&#57;&#50;&#56;&#53;&#55;&#x38;&#x40;&#x31;&#50;&#54;&#x2e;&#99;&#111;&#109;">&#67;&#54;&#57;&#50;&#56;&#53;&#55;&#x38;&#x40;&#x31;&#50;&#54;&#x2e;&#99;&#111;&#109;</a><br>Lon Kai Pang <a href="mailto:&#76;&#111;&#x6e;&#x4b;&#97;&#x69;&#x2e;&#x50;&#97;&#110;&#x67;&#64;&#98;&#x63;&#109;&#x2e;&#x65;&#x64;&#117;">&#76;&#111;&#x6e;&#x4b;&#97;&#x69;&#x2e;&#x50;&#97;&#110;&#x67;&#64;&#98;&#x63;&#109;&#x2e;&#x65;&#x64;&#117;</a>; Baylor College of Medicine;<br>Ruiying Zhao <a href="mailto:&#x52;&#x75;&#105;&#121;&#x69;&#110;&#103;&#x2e;&#90;&#104;&#x61;&#x6f;&#x40;&#117;&#116;&#104;&#x2e;&#116;&#x6d;&#99;&#x2e;&#101;&#x64;&#x75;">&#x52;&#x75;&#105;&#121;&#x69;&#110;&#103;&#x2e;&#90;&#104;&#x61;&#x6f;&#x40;&#117;&#116;&#104;&#x2e;&#116;&#x6d;&#99;&#x2e;&#101;&#x64;&#x75;</a>; McGovern Medical School<br>Weitao Yao <a href="mailto:&#122;&#108;&#x79;&#x79;&#x79;&#x61;&#x6f;&#119;&#x65;&#105;&#116;&#x61;&#x6f;&#x31;&#52;&#x30;&#x32;&#64;&#x7a;&#122;&#x75;&#46;&#101;&#x64;&#117;&#x2e;&#99;&#x6e;">&#122;&#108;&#x79;&#x79;&#x79;&#x61;&#x6f;&#119;&#x65;&#105;&#116;&#x61;&#x6f;&#x31;&#52;&#x30;&#x32;&#64;&#x7a;&#122;&#x75;&#46;&#101;&#x64;&#117;&#x2e;&#99;&#x6e;</a></p>
<h2 id="Cover-letter"><a href="#Cover-letter" class="headerlink" title="Cover letter"></a>Cover letter</h2><p>Dear Editors:</p>
<p>We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “<strong>Journal Name</strong>”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.</p>
<p>In this work, we evaluated <strong>…… (简要介绍一下论文的创新性)</strong>. I hope this paper is suitable for “<strong>Journal Name</strong>”.</p>
<p>We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below.</p>
<p>Thank you and best regards.</p>
<p>Yours sincerely,</p>
<p>Xinhui Du</p>
<p>Corresponding author:</p>
<p>Name: Xinhui Du<br>Email: <a href="mailto:&#x7a;&#x6c;&#121;&#121;&#100;&#117;&#120;&#105;&#x6e;&#x68;&#117;&#105;&#x32;&#55;&#56;&#53;&#64;&#122;&#x7a;&#117;&#46;&#x65;&#100;&#117;&#x2e;&#x63;&#x6e;">&#x7a;&#x6c;&#121;&#121;&#100;&#117;&#120;&#105;&#x6e;&#x68;&#117;&#105;&#x32;&#55;&#56;&#53;&#64;&#122;&#x7a;&#117;&#46;&#x65;&#100;&#117;&#x2e;&#x63;&#x6e;</a></p>
<h2 id="Acknowledgement"><a href="#Acknowledgement" class="headerlink" title="Acknowledgement"></a>Acknowledgement</h2><p>Special thanks to Sunny and Jessica for their support in preparing the manuscript.</p>
<h2 id="Fundings"><a href="#Fundings" class="headerlink" title="Fundings"></a>Fundings</h2><p>This study was jointly supported by the grants of the National Natural Science Foundation of China (Grant NO. 82102258), the Joint Medical Key Technologies R&amp;D Program of Henan Province (Grant NO. LHGJ20220194), the Key Technologies R &amp; D Program of Henan Province (Grant NO.242102310016, 242102521046).</p>
<h2 id="Conflict-of-interests"><a href="#Conflict-of-interests" class="headerlink" title="Conflict of interests"></a>Conflict of interests</h2><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
<h2 id="Data-availability-statement"><a href="#Data-availability-statement" class="headerlink" title="Data availability statement"></a>Data availability statement</h2><p>Not applicable. </p>
<h2 id="Author-information"><a href="#Author-information" class="headerlink" title="Author information"></a>Author information</h2><p>Xinhui Du1*, Boya Zhang1*, Hua Wei2*, Bowen Hu2, Chunyi Shen3, Yuanyuan Wang4, Yafeng Dong5, Wenlong Chang5, Lon Kai Pang6, Ruiying Zhao7, Weitao Yao1</p>
<p>1 Bone Soft Tissue Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.<br>2 Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.<br>3 Biotherapy Center，the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.<br>4 Pathology Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.<br>5 Radiology Department, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.<br>6 Baylor College of Medicine, Houston, TX, United States.<br>7 Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.</p>
<ul>
<li>The authors contributed equally.</li>
</ul>
<p>#Correspondence to Xinhui Du, 127 DongMing Rd, JinShui, Zhengzhou, Henan 450008, China. Email: <a href="mailto:&#122;&#108;&#x79;&#x79;&#100;&#x75;&#120;&#105;&#110;&#104;&#x75;&#105;&#x32;&#x37;&#x38;&#x35;&#64;&#x7a;&#122;&#x75;&#x2e;&#101;&#x64;&#x75;&#46;&#99;&#x6e;">&#122;&#108;&#x79;&#x79;&#100;&#x75;&#120;&#105;&#110;&#104;&#x75;&#105;&#x32;&#x37;&#x38;&#x35;&#64;&#x7a;&#122;&#x75;&#x2e;&#101;&#x64;&#x75;&#46;&#99;&#x6e;</a></p>
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